Two key protein structures in the body are being visualized for the first time, thanks in part to the latest technology in ...

The atomic structures of ADAM17 and iRhom2, revealed by UC researchers, offer new avenues for developing precise treatments ...

Two of the most striking features of mice lacking Adam17 are the hypoplastic crypts in the small bowel and the very low rate of epithelial production, which are almost certainly due to the fact ...

The Seegar Lab used advanced cryogenic electron microscopy techniques to visualize the structure of the ADAM17 enzyme bound to its regulator protein, iRhom2, and identify key elements vital for its ...

Adding a new level of complexity to the function of ADAM17, we finally show that, through the cleavage of VASN, the metalloprotease controls TGFβ-mediated epithelial-to-mesenchymal transition.

Coronaviruses stimulate the activation of a disintegrin and metalloprotease 17 (ADAM17) and shed the extracellular domain of ACE-2 from the cell's surface, thereby, aggravating inflammatory responses.

Study: ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.Image Credit: Design_Cells / Shutterstock. Background. Previous studies have revealed that S is a ...

Improved ADCC with ADAM17 gene knockout of NK or CAR NK cells, supporting ADAM17 KO use for clinical applications Increased specific killing of cancer cells in vitro by the combination of NKX101 ...

ADAM17 identified as a pathogenic gene in families with hair loss. Oct. 17, 2023. No Comments. Researchers from Shanghai Jiao Tong University and affiliated organizations presented data from a study ...

ADAM17 inhibition sensitizes ovarian cancer cells to olaparib treatment, 3D model shows. Dec. 16, 2024. No Comments. Poly (ADP-ribose) polymerase (PARP) inhibitors are used as maintenance therapy ...