We identified a loss-of-function mutation in ADAM17, which encodes a ... and DSG2 mutations are associated with arrhythmogenic and dilated cardiomyopathies. 16,17 The relationship ...

Background: Oncogenic mutations in the small GTPase c-Kirsten (K)-ras occur in 40%-45% of patients with advanced colorectal cancer (CRC) and are challenging in development of anti-cancer therapeutics.

Coronaviruses stimulate the activation of a disintegrin and metalloprotease 17 (ADAM17) and shed the extracellular domain of ACE-2 from the cell's surface, thereby, aggravating inflammatory responses.

This process involves ADAM17 cleaving (shedding) the signaling molecules from their precursor forms in the membrane of a cell. The "pseudoprotease" iRhom2 aids in the maturation and transport of ...

In a new study, researchers from the University of Copenhagen have discovered how the protein PP2A can inhibit tumour growth in mice. The protein turns off an enzyme that stimulates cell growth ...