The researchers also highlighted its potential applications in medicine, agriculture, and aging science by uncovering its reliance on androgen presence and receptor activity. They believe that the ...

In contrast to other steroid receptors, such as ERα, the activation function of androgen receptor (AR) is largely dependent on its ligand-independent AF-1 located in its N-terminal domain (NTD).

The study found that when androgen receptor (AR) binds with testosterone or dihydrotestosterone, the activated receptor binds, as expected, to segments of DNA called androgen response elements.

AR (androgen receptor) – Plays a crucial role in male traits and prostate cancer progression. AR-V7 (a variant of AR) – Linked to castration-resistant prostate cancer (CRPC), which continues ...

Traditional therapies targeting androgen receptor (AR) signaling have limited efficacy. In a recent study, researchers investigated the potential of azolato-bridged dinuclear platinum(II ...

A subset of patients with breast cancer may benefit from treatment with enobosarm, a novel oral selective androgen receptor agonist ... with breast cancer who had AR-positive, ER-positive ...

Arvinas’ second generation PROTAC ® androgen receptor (AR) degrader for patients with prostate cancer. The transaction also includes an asset purchase agreement for the sale of Arvinas ...

Castration resistance is not unexpected, it is the inevitable outcome of chronic, prolonged exposure to androgen receptor (AR) blockade. The length of this period usually varies. However ...