The large amount of acetylsalicylic acid consumed and the variety of its therapeutic uses call for a sound evaluation of its safety based on the scientific literature that it has evoked.

The increased risk of severe bleeding with use of acetylsalicylic acid (ASA) (odds ratio 2.2 ... 2 Use of ASA was associated with a lower risk of cardiovascular events (hazard ratio [HR] 0.89, 95% ...

It is now commercially biosynthesized from phenylalanine. Acetylsalicylic acid (aspirin), a prodrug to salicylic acid, is made by an entirely different process. Curiously, salicylic acid is also a ...