The alt text for this image may have been generated using AI. Despite this obvious lack of efficiency, the challenges imposed by the inherent difficulties in the creation of all-carbon quaternary ...

Organic synthesis is based on carbon-carbon bond formation. Aldol condensation is one of the key reactions, forming a new β-hydroxy carbonyl compound through the reaction of two carbonyl compounds.

A procedure for the preparation of optically pure α-keto-γ-hydroxy carboxylic acids through stereospecific aldol addition catalyzed by pyruvate aldolases from the Entner–Doudoroff and the ...