Potential Best-In-Class Bispecific Antibody ATI-052 Targets Both Thymic Stromal Lymphopoietin (TSLP) and Interleukin-4 ...

The stronger the binding to antigen, the greater the chance the B cell has of surviving and multiplying — a classic Darwinian mechanism of selecting cells that produce high-affinity antibodies.

Each antigen has distinct surface features, or epitopes, resulting in specific responses. Antibodies (immunoglobins) are Y-shaped proteins produced by B cells of the immune system in response to ...

The partnership will use Debiopharm's AbYlink conjugation tech in combination with Alkyon’s modular antibody platform.

New CAR T-cell therapy shows remarkable efficacy in treating relapsed multiple myeloma, achieving high response rates and ...

Fragment Antigen-Binding (Fab) Fragments: These fragments have the antigen-binding regions sans the Fc region, thus reducing ...

Extracellular or exogenous antigens are taken up into specialized antigen presenting cells (APCs) by endocytosis (5). The antigen is degraded in a lysosome (6) into immunogenic peptides which bind ...

Help is now there for those diagnosed with hard-to-treat blood cancers like leukemia and lymphoma, as new therapies are ...

Vaccines have had a major impact on the control of infectious disease, most recently by helping to combat the COVID-19 ...

T cell antigen couplers and TCR fusion constructs hook up their antigen binding domains to the CD3ε domain of an endogenous TCR. 34,35 Because these receptors do not have the intrinsic capacity to ...

Although CAR T-cell therapies have reached significant clinical success in hematological malignancies, their utility in solid tumors remains limited. One of the main challenges is the scarcity of ...