Autophagic dysfunction is increasingly being associated with the pathogenesis of neurodegenerative diseases. A recent and direct example is that mutations in the autophagy gene encoding WIPI4 ...

Autophagy is also regulated by the Beclin ... promises to benefit certain diseases (i.e., infectious or neurodegenerative diseases). Sirolimus, a clinically approved immunosuppressive and ...

Substrates for autophagy include many of the protein aggregates that form in neurodegenerative diseases. In normal neurons, autophagy seems to serve a vital housekeeping function, and recent work ...

“Autophagy dysfunction is present across ... modified fruit fly that serves as a model organism for the neurodegenerative disease ALS. Those experiments showed a small but significant increase ...

Further, genetic mutations in neurodegenerative disease-related proteins, such as tau, alpha-synuclein, and huntingtin, were examined to understand their impacts on autophagy. The researchers also ...

In cells, this process is called autophagy. Most neurodegenerative diseases are related to the improper accumulation of cellular waste by-products. Now, for the first time, researchers at the ...

There is evidence that autophagy may improve the outlook for cells with infectious and neurodegenerative diseases by controlling inflammation. Another review article explains that autophagy helps ...

Scientists have identified a potential new target for treating Alzheimer's and other neurodegenerative diseases. The ...

More information: Suhyun Kim et al, Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer's disease, Molecular Neurodegeneration (2024). DOI: 10.1186/s13024 ...

highlighting their continued contribution to unraveling the complexities of autophagy-mediated protein secretion in neurodegenerative disease contexts. Dr. Dash says, "Our study reveals a unique ...

"In the early stages of several neurodegenerative diseases, autophagy is compromised, which means cells have a reduced repair capacity," Selleck said. "In this study, we determined that heparan ...