Drugs that specifically inhibit BCR signaling elements are currently ... novel therapeutic strategies for the management of B-CLL. B-cell receptor-activation pathways following antigenic stimulation.

In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Figure 4: Impaired antigen receptor–activated B cell proliferation and humoral responses in Vav-deficient mice. Figure 5: Vav-2 in BCR signaling and tyrosine phosphorylation in Vav-1 −/− Vav ...

Dr. David A Braun delved into detail on the molecular factors driving exceptional responses to immunotherapy in metastatic ...

In the IO/VEGF cohort, patients who had exceptional responses showed a strong presence of B-cell receptor signaling pathways and tertiary lymphoid structures (where immune cells gather before ...

Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor,” published in the January 2025 issue of Allergy ...

How do cells forming organs or repairing tissues know when to stop growing? Adhesion receptors act as molecular ... Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.

T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...