A study reveals significant genomic differences in metastatic prostate cancer among veterans, highlighting the need for ...

CDK12 is established as a tumor suppressor in prostate cancer, ... (AR) signaling in CDK12KO ... (AKT) pathway. The CDK12/13 inhibitors, YJ5118 and THZ53, showed stronger effects. Based on the ...

Metastatic ovarian, prostate and breast cancers are notoriously difficult to treat and often deadly. Now, researchers have revealed a new role for the CDK12 protein.

To understand how CDK12 loss impacts cells on a molecular level, ... Further, they found that knocking down CDK12/13 activated the AKT pathway, which plays a role in cancer development.

The DNA double-stranded break repair pathway is enriched for genes with longer transcripts that are preferentially downregulated by CDK12 inhibition. CDK12 inhibition induced DNA damage, while ...

By Pooja Toshniwal Paharia Breakthrough research sheds light on the genetic mutation behind aggressive prostate cancer. Study: CDK12 loss drives prostate cancer progression, transcription ...