Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

Some NSAIDs with a moderate potency to inhibit COX-2 over COX-1, such as nimesulide and meloxicam, were claimed as being 'COX-2 selective' and the new COX-2 selective compounds, able to spare the ...

Selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory medication (also known as NSAIDs). Over-the-counter NSAID medications include aspirin, ibuprofen (Advil, Motrin, and other ...

Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

Yepuri, MDNon-steroidal anti-inflammatory (NSAID) medications are often a first-line recommendation for over-the-counter (OTC ...

It differs from non-selective NSAIDs because it targets the COX-2 enzyme, primarily involved in inflammation. Celebrex works ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...