When a chef develops a new recipe, they methodically add and remove individual ingredients to see how each of them alters the final dish. When scientists try to understand the role of genes in the ...

Alongside CRISPR/Cas9 and TALEN, zinc finger nuclease is an important tool in the field of genome editing. Engineered to break certain bonds within the polynucleotide chain of a DNA molecule, these ...

In a paper, published on 24 August, scientists from the National Agri-Food and Biomanufacturing Institute genetically ...

The results of a metagenomic study from the University of Trento suggest that the CRISPR toolbox will need to make room for another CRISPR enzyme. The disruption should be minimal because the newly ...

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein ...

CRISPR-Cas gene editing has transformed research and industry, enabling precise genome modification for diverse applications, including therapeutic development. However, this method is not without ...

Scientists at St. Jude Children's Research Hospital have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors. A revolution in ...

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel ...

Elizabeth Kellogg, PhD, St. Jude Department of Structural Biology, used cryo-EM to study the evolutionary journey of Fanzor2, a compact eukaryotic genome-editing protein with huge potential. (MEMPHIS, ...