In children, cancer probably arises from a combination of inherited genetic mutations and genetic alterations that are acquired during the rapid cellular expansion that occurs during embryogenesis ...

Regulated necrosis is defined as a genetically controlled cell death process that eventually results in cellular leakage, and it is morphologically characterized by cytoplasmic granulation, as ...

Cellular damage associated with necrosis also drives core aging processes such as genomic instability, proteostasis loss, telomere shortening, oxidative stress and epigenetic alterations. Another ...

Cellular aging may explain persistent liver stiffness after HCV eradication, with shorter telomeres linked to poorer hepatic ...

We target the cellular injury that leads to cell death and organ failure using molecules that inhibit necrosis. Prof. Amnon Albeck participated in the research. Smart Funding is helping to raise ...

A critical next step for this work is to understand how senescent changes in late life trigger such destructive waves of cellular necrosis. Conclusions In this study, we have documented a phenomenon ...

Additionally, we did not identify any significant number of ghost cells – a state of late-stage cellular necrosis – in the light micrographs analyzed. Using transmission electron microscopy of tissue ...

Avascular necrosis is a common complication of sickle cell disease. Learn what symptoms to look for, how it’s treated, and what it means for your outlook.

Smoke inhalation can cause potentially fatal pulmonary injury and its occurrence is frequently underestimated. The three primary processes that lead to inhalation injury include: thermal injury ...