Organization of DNA into chromatin is likely to participate in the control of the timing and selection of DNA replication origins. Reorganization of the chromatin is carried out by chromatin ...

The paper, "Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity," published Oct. 17 in Cell. During DNA replication -- as a replisome splits two DNA strands and ...

The histone chaperone, Asf1, coordinates the removal of histones from the chromatin to allow the replication machinery to move along the DNA, with the supply of new histones to reform the ...

This study proposes a new mechanism by which Chd1 senses and responds to DNA unwrapping via EDBL engagement to suppress ...

Chromatin remodeling is an important mechanism ... such as transcription factors and components of DNA replication. In the cell nucleus, the DNA double helix is tightly wrapped around nuclear ...

This key difference could affect how genes are accessed and used by the cell to regulate important processes like gene expression and DNA replication. "These differences in chromatin behavior are ...

If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally segregated, leading to genetic ...

Ph.D., and colleagues have generated a "catalog" of the proteins present at sites of DNA duplication (replication forks) and chromatin packaging of newly synthesized DNA. They demonstrated the ...

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic acid hybridization to fish out specific DNA sequences along with the bound proteins. By using enzymes ...

2024.07.017]. The scientists determined that Mrc1 and Mcm2 form a co-chaperone complex, ensuring distribution of histones to the lagging strand during DNA replication. In mutants of Mrc1 ...