The new work involved determining the structure of an error-prone enzyme ... "This information may lead to new cisplatin derivatives able to escape translesion replication in order to overcome ...

Cisplatin has been used as a treatment for cancer since its approval by the US Food and Drug Administration in 1978. And while five other platinum drugs based on the structure of cisplatin have ...

A new study using ovarian cancer cell lines shows promise in treating the deadly disease by combining the chemotherapy drug cisplatin with ... from the aspirin derivative NCX-4016 reacts with ...

Now, researchers have discovered that the new drug NCX-4016, an aspirin derivative, re-sensitizes ovarian cancer cells to chemotherapy with cisplatin and also kills ovarian cancer cells. Although this ...

A new study using ovarian cancer cell lines shows promise in treating the deadly disease by combining the chemotherapy drug cisplatin with ... from the aspirin derivative NCX-4016 reacts with ...