They also found that antipsychotics with high binding affinity for serotonin (serotonin 1A, 5-HT2A, serotonin 6, and serotonin 7), dopamine (D2 and D4), histamine (H1), muscarinic (M1), and ...

Although all current antipsychotics act by interfering with the action of dopamine at dopamine D2 receptors ... the binding of [3 H]domperidone to the high-affinity site (at D2High receptors ...

Treatment-resistant schizophrenia is a disabling illness, affecting approximately 8 million people worldwide with profound effects on patients, families, and society.1,2 Clozapine is the gold standard ...