To accomplish this, each strand of existing DNA acts as a template for replication. The initiation of DNA replication occurs in two steps. First, a so-called initiator protein unwinds a short ...

incorporation in the nascent strand during DNA replication followed by selective degradation of the nascent strand to isolate the template strand for construction of directional sequencing libraries.

The two separating strands become the replication fork. On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand of complementary ...

DNA replication is required to maintain the ... The unwound single-stranded DNA templates move toward the complex; the behavior of the clamp loader on the leading and lagging strand differ because ...

Once the leading-strand polymerase resumes DNA synthesis, it catches up to the helicase and rapid template unwinding and replication can continue (Fig. 3). We have termed this fail-safe mechanism a ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

The presence of POLG2 decreases the proofreading ability of Pol γ due to its poor ability to mediate the transfer of the template ... H-strand synthesis. Initiating mitochondrial DNA replication ...

RNA produced within cells of a common budding yeast can serve as a template ... chromosomal DNA is dangerous for cells because it may impair transcription elongation and DNA replication, promoting ...

DNA polymerization is a semi-conserved process that utilizes both strands of a double-stranded DNA molecule as a template for replication. RNA polymerase is an attractive target for drug development ...

The two separating strands become the replication fork. On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand of complementary ...

The two separating strands become the replication fork. On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand of complementary ...