Drug discovery requires two separate steps: checking whether a drug can bind to a harmful molecule or its receptor, and ...

Thousands of proteins are known to cause disease, but while the biological activity of these proteins is understood, the way to hit and modulate them with a drug is not. Nature still has ways to bind ...

In a recent study published in Virology, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) drugs that compete for nucleotide-binding pockets (NBPs) of SARS ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs. In recent years, models like ...

For decades, scientists across the globe have investigated methods to accurately measure drug permeability across the blood-brain barrier, a compact layer of cells that protect the brain from ...

Misbehaving proteins are behind many diseases. One way drugmakers incapacitate these bad actors is to deploy molecules that bind to them. But finding solid footholds on the proteins to block their ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Researchers at Nano Life Science Institute (WPI-NanoLSI) and the Cancer Research Institute at Kanazawa University have ...

Relapses in a common form of leukemia may be preventable following new research which has identified how the cancer develops resistance to first line treatments. New research published in iScience by ...