Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the ...

Efflux Pump’s Shape Shifting Sheds Light on Antibiotic Resistance February 18, 2022 MIT chemists have discovered how the structure of the EmrE transporter changes as a compound moves through it.

The efflux pumps had, in effect, given the microbes the exact loophole they needed to resolve the protein synthesis paradox. The pumps weren’t enough to confer drug resistance on their own ...

Different types of efflux pump proteins might have evolved independently, instead of divergently as previously thought. This could yield insights in mediating antibiotic resistance.

The classic multidrug-resistance (MDR) phenotype, as mediated by the drug efflux pump, P-glycoprotein, is one of the most extensively studied mechanisms of drug resistance. Additional drug ...

Researchers have described a new class of molecules that inhibit efflux pumps so that antiboitics remain effective. The World Health Organization has labeled antimicrobial resistance a global ...

Universal embezzlers naturally emerge in critical fermion systems, study finds. Jun 21, 2025. ... A novel inhibitor capable of disabling a key Mycobacterium tuberculosis efflux pump has been ...

Scientists at the University of Cambridge have uncovered the final piece in the jigsaw revealing the structure of ‘efflux pumps’, which allow Salmonella and other disease-causing bacteria to develop ...

These efflux pump modulators (EPMs) were discovered in an in-cell screening platform called SAFIRE (Screen for Anti-infectives using Fluorescence microscopy of IntracellulaR Enterobacteriaceae).