and in several other PARP-family members. Instead, the authors can model Glu882 as the catalytic PARP10 'substrate' in a reaction carried out by a second PARP10 enzyme. Such substrate-assisted ...

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis ... and its importance is reflected in its abundance: this enzyme is one of the most common nuclear proteins.3 When PARP1 binds damaged DNA, it ...