At the signaling level, the extracellular signal-regulated kinase (Erk)-activator protein 1 (Ap1) pathway seems to mediate the effects of LNFPIII on both inflammatory and metabolic pathways.

Reference: Ge Z, Zhu YL, Zhong X, Yu Jk, Zheng S. Discovering differential protein expression caused by CagA-induced ERK pathway activation in AGS cells using the SELDI-ProteinChip platform. World ...

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases ...

Figure 1. Main readouts for GPCR signaling pathway investigations, including cyclic AMP, IP1, and p-ERK. Advanced Phospho-ERK1/2 Assay. These assay miniaturization and detection issues have led ...

Next, by analyzing colons of mice in which obesity was induced by a high-calorie diet, it was found that colonic inflammation, along with both hepatic ERK pathway activation and increased β-cells ...

A BUSY HORMONE:© 2001 Annual ReviewsEstrogen's direct genomic effects are mediated by the nuclear form of the estrogen receptors ERα or ERβ which associate with the Estrogen Response Element (ERE) or ...

Therefore, ERK inhibition may provide the opportunity to avoid or overcome resistance from upstream mechanisms, as it is the most distal kinase of this signaling pathway. About JSI-1187 ...

The low response rate—20%—is comparable to response rates observed in other treatments, such drugs that target MEK enzymes in the MAPK/ERK pathway.

PI3K/AKT and MEK/ERK pathways targeted in new therapy for docetaxel-resistant prostate cancer. Download PDF Copy; Reviewed. Germans Trias i Pujol Research Institute Feb 5 2024.