The movement of leukocytes (white blood cells) from the bloodstream to the surrounding tissue (extravasation) is a prerequisite for effective immune responses. To enter a site of inflammation, ...

Chemoattractants direct the extravasation of leukocytes to the site of immune response. New data highlight the role of synaptotagmins and Rab proteins in leukocyte chemotaxis. You have full access ...

At sites of infection or inflammation, these leukocyte integrins become activated and mediate adhesion and extravasation of the leukocyte into the infected tissue. Activated integrins latch onto ...

Rolling, adhesion, and transmigration of leukocytes were initially described by scientists in the nineteenth century. With the discovery of chemokines, chemokine receptors, integrins and selectins ...

The β 2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2, which encodes CD18 ...

Extravasation is a process wherein leukocytes migrate from the tissues to the blood and from the lymphatic vessels back into the tissues. The binding of chemokines to extracellular matrix ...

In a second part, it will be investigated whether the preferential use of the leukocyte diapedesis route through endothelium (trans-junctional versus transcellular) varies in different organs and ...

The movement of leukocytes (white blood cells) from the bloodstream to the surrounding tissue (extravasation) is a prerequisite for effective immune responses. To enter a site of inflammation, ...