Study participants with genetic variants in GSK3B all presented with similar symptoms, including developmental delay, autism, sleeping disturbances and other behavioral challenges.

GSK3B has always been an appreciated molecule in the treatment for Alzheimer's disease. However, clinical trials with all potential inhibitors caused adverse effects, which were a disappointment.

"GSK3B has always been an appreciated molecule in the treatment for Alzheimer's disease. However, clinical trials with all potential inhibitors caused adverse effects, which were a disappointment.

An international study links GSK3B gene variants to autism and developmental delays. By analyzing 15 cases and using mouse models, researchers showed disrupted development in excitatory neurons.

By inhibiting GSK3B in mice, investigators observed that expected development was disrupted and led to a neurodevelopmental disorder with similar features to autism. The findings will add to existing ...