The protein is implicated in a wide swath of cancers, but harnessing it for drug R&D is still a major scientific challenge.

As we age, our cells accumulate genetic changes—mutations—some of which open the door to cancer. Scientists call these ...

The gene p53 acts as a tumor suppressor and often is called the ‘guardian of the genome.’ This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading ...

The gene p53 acts as a tumor suppressor and is often called the guardian of the genome. This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading to ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in ...

The p53 gene status (mutation) and protein alterations (nuclear accumulation detectable by immunohistochemistry; p53 protein status) are associated with bladder cancer progression. Substantial ...

The results of research headed by a team in the lab of Michael Sigal, MD, at the Max Delbrück Center and Charité—Universitätsmedizin Berlin, have shed new light on the role of the p53 tumor suppressor ...

Characterizing the clinical and genomic features of androgen indifferent prostate cancer. Distribution of manual p53 scores (rows) and automated digital image analysis (DIA) p53 scores (columns) by ...

In 1977, Richard Peto, a British epidemiologist, theorized that large-bodied animals like elephants are more likely to ...