This association was specific for LRRK1, because LRRK2 did not interact with Grb2 . Figure 1: LRRK1 forms a complex with EGFR via Grb2 in response to EGF stimulation. (a ...

Wild type LRRK2 is readily digested by the lysosomes via CMA, however, its disease-causing variants are poorly degraded by this pathway (Orenstein et al., Nature Neuroscience 2013). CMA-mediated ...

Future Neurology. 2012;7(2):145-153. Taken together, the present studies do not support a direct biochemical interaction between α-syn and LRRK2, or direct phosphorylation of α-syn by LRRK2 ...

We detected Lrrk1 as a component of the Grb2/Gab2/Shc1 complex and found that it functionally interacts with the regulator of small GTPases Arap1 ... (Sgk223) and Lrrk1 (Lrrk2 paralog).

More information: Chen, C. et al, LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons, Molecular Psychiatry (2025). DOI: 10.1038/s41380-025-03030-z Provided ...

The role played by mutations in the LRRK2 gene in promoting Parkinson’s disease has long intrigued scientists, and even led to an experimental drug that inhibits the over-active protein. Yet exactly ...

Once considered merely a passive link between proteins that matter, Grb2 - pronounced "grab2" - actually lives up to its nickname with its controlling grip on an important cell signaling pathway, ...

Findings from 23andMe research on Parkinson’s disease published in BrainThe LRRK2 variant is strongly associated with symptoms of Parkinson’s disease (PD) that are different from non-variant ...

A big reason for this was the softness, or "floppiness," of GRB2 and SOS1, making them difficult to study with tools like X-ray crystallography and cryo-transmission electron microscopy.

Tokyo, Japan – Researchers from Tokyo Metropolitan University have uncovered new insights into how the proteins GRB2 and SOS1 in cells pass signals from membrane receptors to nuclei. They used ...

Biogen and Denali Therapeutics have begun dosing the first participants in a phase 3 study to evaluate the efficacy and safety profile of BIIB122 (DNL151) in approximately 400 patients with ...