The Grignard reaction is a powerful, frequently used organometallic transformation to add important structural motifs to carbonyl compounds resulting in secondary or tertiary alcohols. Since usually ...

Am. Chem. Soc. 2020, DOI: 10.1021/jacs.9b11829) In a Grignard reaction, a carbon-bonded magnesium halide adds to a carbonyl group to form an alcohol. Textbooks explanations describe the reaction ...

It is widely recognized that the Barbier–Grignard-type reaction is one of the most important methods for forming carbon–carbon bonds and has widespread synthetic applications in modern organic ...

Example: Reaction of a Grignard reagent with a carbonyl compound. In oxidative addition, the organometallic complex increases its oxidation state by adding a molecule across its metal centre.

At Osaka University, a team of organic chemists has now developed and enhanced a chemical reaction that allows controlled transformations of one of the toughest chemical bonds. “We previously ...

The team successfully synthesized several azides by the Grignard reaction, paving the way for the synthesis of a broad range of organonitrogens (amines and triazoles) for industrial applications.