Genome instability and intratumor heterogeneity are closely associated, as genome instability increases the rate of mutation (in the broadest sense referring to nucleotide and to whole chromosome ...

Mitigating some of the most significant consequences of intratumoral heterogeneity is that the essential oncogenic driver mutations on which the growth and progression of many tumors depend are ...

The book takes into account a wide range of factors, including stochastic elements that produce somatic genetic heterogeneity, offering insight into the evolutionary nature of intercellular ...

Cellular phenotypic heterogeneity, an important hallmark of cancer, poses a significant hurdle for cancer therapy. A central tenet of the laboratory is to utilize genetically engineered mouse models ...

This is called tumor heterogeneity. As cancer progresses, the tumor begins to consist of more diverse cells with a range of molecular signatures and variable sensitivity to treatment. Skip to content ...

Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.To examine intratumor heteroge ...

Heterogeneity in the polysaccharide constituents of plant cell walls has been recognized since the earliest chemical analyses of isolated wall preparations. Clear and dramatic differences in ...

Density physics-informed neural networks reveal sources of cell heterogeneity in signal transduction. Patterns , 2023; 100899 DOI: 10.1016/j.patter.2023.100899 Cite This Page : ...

Takeuchi, Hirotaka, and Yoko Ishikura. Ishitsu no Management: Nihonteki Doushitsu Keiei wo Koete (Managing Heterogeneity: Beyond Japanese-style Homogeneous Management). Daiyamondosha [Diamond, Inc.], ...