The most widely held hypothesis on the pathogenesis of IBD is that overly aggressive acquired (T cell) immune responses to a subset of commensal enteric bacteria develop in genetically susceptible ...

Investigating the relationship between IL-1 and inflammation in inflammatory bowel disease (IBD), researchers unveiled mesenchyme homeobox 1 (MEOX1), an IL-1-dependent transcription factor that is ...

Where genes are associated with CD and UC, the p-values are given from the index gene discovery study; this is CD for all the genes presented here. * Colonic CD only. ‡ Early-onset disease ...

Thus, focusing on the ability of this model to portray UC pathophysiology, the research team next tested the effects of a commonly used drug for treating UC, tofacitinib, in IBD-like colonic ...

Background GPR171 suppresses T cell immune responses involved in antitumour immunity, while its role in inflammatory bowel disease (IBD) pathogenesis remains unclear. Objective We aimed to investigate ...