Silencing of aurora kinase A results in less phosphorylation of p53 at Ser315, greater stability of p53 and cell-cycle arrest at G2-M. Cells depleted of aurora kinase A are more sensitive to ...

Polo-like kinase 1 (Plk1) controls multiple aspects of mitosis and is activated through its phosphorylation at Thr210. Here we identify Ser99 on Plk1 as a novel mitosis-specific phosphorylation ...

May 15, 2007 (Vol. 27, No. 10) Regulating Fundamental Cellular Processes Such as Proliferation, Differentiation, and Apoptosis Kinases are enzymes that catalyze the transfer of phosphate groups ...

Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...

The phosphorylation of proteins represents the basis of numerous cellular processes, ... Kinase-targeted cancer therapies: progress, challenges, and future directions.

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, ... the HIPK2 deficiency and apoptosis signaling acted via decreased ERK1/2 kinase phosphorylation.

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. ... (*1) Protein phosphorylation.

A study from Fujita Health University reveals that chronic hyponatremia in mice results in anxiety-like behaviors due to ...