The 'kynurenine pathway' is a series of chemical reactions ... This process involves several byproducts including kynurenic acid (neuroprotective) and quinolinic acid (neurotoxic).

1. The principal branch for tryptophan metabolism generates quinolinic acid and nicotinamide, whereas the side branches generate kynurenic acid and xanthurenic acid. The various enzymes of the ...

Quinolinic acid and kynurenic acid are byproducts of one of the body’s cellular energy pathways. The disruption of this pathway can create an imbalance of quinolinic acid relative to kynurenic acid.

"The kynurenic acid pathway and the inhibitory effects of the compound are also found in mammals," Ashrafi noted. "But it remains to be determined whether kynurenic acid influences learning in ...

The kynurenine pathway is the principal pathway by which ... The conversion of kynurenine to kynurenic acid by kynurenine aminotransferases (KATs) in the periphery, however, limits kynurenine ...

In a study published today in the journal Science Signaling, the authors report that male COVID-19 patients were more likely than female patients or healthy control subjects to have elevated levels of ...

To do so, they identified that Ro 61-8048 interfered with the chemical pathway kynurenic acid takes through brain cells, creating a metabolic blockage so that kynurenic acid levels artificially rose.

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In the present study, researchers investigated the probable impact of kynurenic acid (KYNA), a product of the normal metabolism of amino acid L-tryptophan, on the viability of cardiac cells after ...