To overcome the low reactivity of the ketones, highly reactive lithium-based reactants, called lithium acetylides, are added. However, their reactivity is often insufficient for use with ketones.

To overcome the low reactivity of the ketones, highly reactive lithium-based reactants, called lithium acetylides, are added. However, their reactivity is often insufficient for use with ketones.

Chiral Macrocyclic Catalysts for the Enantioselective Addition of Lithium Acetylides to Ketones. Journal of the American Chemical Society , 2023; 145 (48): 26238 DOI: 10.1021/jacs.3c08905 Cite ...