Lysosomes are dynamic organelles that receive membrane traffic input from the secretory, endocytic, autophagic and phagocytic pathways. They can also fuse with the plasma membrane. Live-cell imaging ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes. Lysosomes ...

Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when the cellular ...

Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is ...

Ishikawa, Japan - The correct functioning of our cells rests upon the precise orchestration of many complex processes and organelles. Lysosomes—vital cell organelles—are enzyme-filled subunits found ...

Janelia researchers have uncovered a novel way that two of the structures inside cells—the endoplasmic reticulum (ER) and lysosomes—coordinate the production of proteins, highlighting how interactions ...

Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell's lysosomes. The breakthrough ...

Northwestern Medicine scientists have identified the consequences of contact between the mitochondria and the lysosome in the axons and synapses of human neurons, according to a study published in ...

The lysosome was once thought of as the trash can of the cell, a dead-end destination where cellular debris was sent for disposal. But a growing body of research shows that this enzyme-filled vesicle ...

Mutations in the progranulin gene cause a form of frontotemporal dementia, most likely because levels of the protein fall in the central nervous system. How this affects brain function is unknown.