The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to leukemia therapy. Dysregulated signaling ...

The Raf–MEK–ERK pathway couples growth factor, mitogenic and extracellular matrix signals to cell fate decisions such as growth, proliferation, migration, differentiation and survival1,2. Raf ...

The MAPK pathway is more accurately termed the RAS-RAF-MEK-ERK pathway, and involves the regulation of cell proliferation and survival. It is constitutionally overactive in 30% of cancers.

A combination of human anti-cancer drugs has been shown to increase the lifespan of mice by nearly 30%. This discovery opens up unprecedented prospects for aging research. The drugs in ...

Conclusions: Signaling output in RAS mutant cancers occurs through both the PI3K-AKT-mTOR and RAF-MEK-ERK pathways and thus those cancers are more likely to benefit from dual blockade. Pts with RAS ...

Together, these studies uncover novel compensatory pathways that may be involved in tumor adaptation to inhibition of the KRAS–RAF–MEK–ERK pathway.

PI3K/AKT and MEK/ERK pathways targeted in new therapy for docetaxel-resistant prostate cancer. Download PDF Copy; Reviewed. Germans Trias i Pujol Research Institute Feb 5 2024.

Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that inhibition ...

JS InnoPharm Initiates Treatment With JSI-1187, a Selective ERK Inhibitor, ... MAPK signaling via the RAS-RAF-MEK-ERK pathway plays a critical role in cancer growth and proliferation.

The consequent aberrant signaling through the RAF–MEK–ERK pathway 38 shapes key traits of HCL, including its unique expression signature, hairy appearance, and inhibition of apoptosis 39 .

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases ...