Human, Proof-of-Mechanism Phase 1 Study of the Oral MRGPRX2 Antagonist SEP-631 Utilizing Short Wave Infrared Imaging to Assess Response to an Icatibant Skin Challenge Poster Number: L58 Session: Late ...

Indolent systemic mastocytosis (ISM) is a type of mastocytosis in which fewer clonal mast cells accumulate, thereby slowing the disease course and offering a better prognosis than other, more ...

For many patients with diverse and seemingly unrelated symptoms, obtaining an accurate diagnosis can take years of specialist visits and inconclusive tests. Mast cell activation syndrome, a disorder ...

Mastocytosis is a group of rare haematological disorders characterised by an abnormal accumulation of clonal mast cells in the skin or other organs, particularly the bone marrow. The condition ...

Please provide your email address to receive an email when new articles are posted on . Barzolvolimab is an anti-KIT monoclonal antibody, and mast cells need KIT to survive. Weekly hive and itch ...

Immune cell trapping during allergic responses Mast cells, residing in tissues and critical for initiating inflammation, are filled with granules containing pro-inflammatory substances. These granules ...

Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy ...

Nurse Amy Lochtie was in a meeting about infection control the first time she went into anaphylaxis — a severe reaction, usually related to an allergy, which can be life-threatening. But in her case, ...

This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), ...