Regarding prevention of bladder toxicity, the authors report that the agent mesna (2-mercatpoethanesulfonic acid), which likely binds to the CYC-metabolite toxic metabolite in the urine ...

Cumulative [cyclophosphamide] doses above 25 g definitely ... Good hydration and treatment with mesna (2-mercaptoethane sulfonate sodium) should not be forgotten," Knight says.

It is used to reduce the bleeding risk from the bladder in patients taking the cancer treating medicine cyclophosphamide or ifosfamide. Mesna is prescribed as a preventive medicine to reduce the ...

The experimental-prophylaxis regimen consisted of the following: cyclophosphamide (50 mg per kilogram per day on days 3 and 4 after HSCT) with mesna and hydration (details are provided in the ...

All patients receiving cyclophosphamide also received mesna (Mesnex, Bristol-Myers Squibb) to prevent hemorrhagic cystitis and granisetron hydrochloride (Kytril, GlaxoSmithKline) to prevent nausea ...

Patients with a creatinine clearance less than 50 ml/min who receive high doses of cyclophosphamide (>750–1,000 mg/m 2) have increased systemic drug exposure. 36 In these patients, MESNA (2 ...

Rates of grade III/IV acute GVHD at 3 months were 3% with cyclophosphamide-cyclosporin prophylaxis and 10% with standard ...

Mesna generic Mesna is prescribed as a preventive medicine to reduce the risk of hemorrhagic cystitis caused by the chemotherapy drugs ifosfamide and cyclophosphamide. Hemorrhagic cystitis is a ...