Multiple acyl-CoA dehydrogenase deficiency (MADD) and related lipid storage myopathies comprise a heterogeneous group of inherited metabolic disorders that impair fatty acid oxidation and cellular ...

Researchers have discovered a mechanism in our cells that is essential to energy production in the muscles. The discovery may lead to new treatment for disorders affecting the muscles, such as ...

Mitochondrial DNA (mtDNA) mutations impair OXPHOS and enhance lactate accumulation in skeletal muscle. Elevated lactate drives H3K14 histone lactylation, inducing GDF15 expression and secretion in ...

The poster highlights the findings of pharmacological and biochemical studies which demonstrate that mavodelpar (REN001) is a potent and selective agonist of peroxisome proliferator-activated receptor ...

We all learned in high school biology that mitochondria are the powerhouse of the cell. But powering up those cellular engines requires a molecular spark. Now, scientists at the Salk Institute have ...