“This is an early but exciting step toward recharging aging tissues using their own biological machinery,” Gaharwar says in ...

The EMA’s positive opinion on Kygevvi marks a turning point for patients with TK2d, an ultra-rare genetic muscle disease previously managed only with supportive care.

Physical rehabilitation and symptom management still remain the mainstay of treatment for stroke, as clot removal or ...

A new study reveals that vesicles packed with healthy mitochondria can supercharge tissue repair and combat chronic disease, paving the way for next-generation regenerative treatments. Study: ...

We all learned in high school biology that mitochondria are the powerhouse of the cell. But powering up those cellular engines requires a molecular spark. Now, scientists at the Salk Institute have ...

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes. Some of these conditions result from ...

Mitochondrial DNA (mtDNA) mutations impair OXPHOS and enhance lactate accumulation in skeletal muscle. Elevated lactate drives H3K14 histone lactylation, inducing GDF15 expression and secretion in ...

When doctors prescribe oxybutynin, it's usually for an unglamorous problem: bladder incontinence. But researchers have discovered a surprising new role for this decades-old drug—one that could open ...

Strength training strengthens muscles, improves blood glucose control, and is said to reduce the risk of cardiovascular ...

For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these mutations cause serious diseases that pass down only through mothers. They ...