The first determination of the atomic structure of Transient Receptor Potential Melastatin 8 (TRPM8), a molecular sensor in nerve ends that detects cold temperatures as well as menthol and other ...

In 2020 lawmakers in California and Massachusetts banned menthol, a chemical that causes a cooling sensation, as an additive in cigarettes. The idea was partly to help curb youth smoking; menthol ...

It includes the WS compounds and considers more broadly the basic structure of menthol and the chemical groups that are added to it. Belgium and the Netherlands consider function in their bans.

"Knowing the atomic structure of TRPM8 and how it reacts to cold, menthol and other stimuli should help in the design of potent and selective new drugs targeting this sensor," said study leader ...