Mechanisms of acquired resistance. The efficacy of paclitaxel is significantly limited by the development of acquired resistance. Two principal mechanisms of resistance have been described for ...

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The primary mechanism of action of paclitaxel involves inhibiting microtubule depolymerization, leading to the termination of mitosis in tumor cells and ultimately causing their death. Paclitaxel is ...

Acta Pharmacologica Sinica - Absorption mechanism of DHP107, an oral paclitaxel formulation that forms a hydrated lipidic sponge phase Skip to main content Thank you for visiting nature.com.

The paclitaxel stent was associated with a higher rate of in-segment ... RT, Lee, RW. Increased incidence of coronary atherosclerosis in type 2 diabetes mellitus: mechanisms and management. Ann ...

Identified mechanism involved in development and intensification of cancer treatment-related pain Scientists who analyzed the combined use of two drugs – paclitaxel and immune checkpoint ...

Among patients undergoing percutaneous coronary intervention (PCI), the use of paclitaxel-eluting stents or sirolimus-eluting stents, as compared with use of bare-metal stents alone, reduces the ...

However, the molecular mechanism by which tubulin acetyltransferases modify microtubules and interact with paclitaxel remains unknown. There is an urgent need for research to clarify these ...

Paclitaxel is a chemotherapy drug widely distributed by the SUS (Sistema Unificado de Saúde), Brazil's national health system, for several types of cancer. In many patients, it causes adverse ...

She successfully demonstrated that paclitaxel was able to prevent cell division via an interesting mechanism – stimulating the development of microtubules (cell's ultrafine filaments).