Researchers have discovered that activating the pentose phosphate pathway makes antitumor CD8+ T cells more likely to stay in an immature, stem-like, “precursor” state. Combining this metabolic ...

As humans age beyond early adulthood, their physical and mental functions tend to slowly worsen over time. One of the most common sources of severe mental decline in older adults are neurodegenerative ...

(a) Proposed protometabolic pentose pathway leading to the accumulation of aldonates followed by nonselective oxidation to uronates, carbonyl migration, and β-decarboxylation. (b) First few steps of ...

Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability on early Earth is unclear since these molecules are unstable. Now, researchers reveal a chemical ...