Zhou et al. show that GSK3β phosphorylates KDM1A and induces its deubiquitylation by USP22, leading to demethylation of histone H3K4 and glioblastoma progression.

ULK1 is recruited to VPS34–Beclin-1 complexes through binding to ATG14L, phosphorylating Beclin-1, and activating the VPS34 kinase and PtdIns(3)P production at the nascent autophagosome.

In fact, phosphorylating a specific spot on the protein called S421 protected a mouse model of Huntington's from developing symptoms of the disease.