A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

Researchers announce the release of an online tool that will help scientists find "gene promoters" -- regions along a DNA strand that tell a cell's transcription machinery where to start reading ...

Insulin Gene Expression . Humans, ... The 5' and 3' 8-bp flanking regions of the insulin promoter A boxes (shown in their natural order along the promoter) were compared with human A boxes.

British Journal of Cancer - A promoter region of the midkine gene that is frequently expressed in human hepatocellular carcinoma can activate a suicide gene as effectively as the α-fetoprotein ...

The biologic effects of the loss of gene function caused by promoter hypermethylation and by coding-region mutations are similar. 4–6 For example, both mutations and promoter hypermethylation of ...

Researchers looked at cells sampled from 308 people with pancreatic cancer, finding mutations in gene promoter regions that provide important clues about pathways perturbed in the illness and ...

A research group at the Stowers Institute for Medical Research says it has put to rest the notion that a gene promoter is only a promoter. They report, in the current issue of eLife Sciences, that ...

As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional ...

Moreover, they observed hypomethylation in the promoter region of RABGGTB, a gene related to autophagy and synaptic function, which corresponds to its heightened expression.

Specifically, many scientists focused on the so-called 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene to research the effects of this gene on depression.