Researchers capture first-of-its-kind video of dynein–Lis1 protein interaction, supporting future drug development for neurological disorders. Our cells rely on microscopic highways and specialized ...

Circadian clocks have evolved as an adaptive mechanism to anticipate daily environmental changes and are recognized as an important regulator of the cellular environment amongst eukaryotes 1. The ...

In drug discovery, determining the binding affinity and functional effects of small-molecule ligands on proteins is critical. Current computational methods can predict these protein–ligand interaction ...

Scientists from Cleveland Clinic and Cornell University have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat ...

Protein-Protein Interactions (PPIs) are critical for biological systems to function properly. Strong interactions maintain structural integrity and function, whereas weaker interactions enable ...

Scientists have used deep learning to design new proteins that bind to complexes involving other small molecules like hormones or drugs, opening up a world of possibilities in the computational design ...

In the human body, the boundary between health and severe illness can be microscopic. For decades, molecular scientists have grappled with a frustrating biological reality: The proteins driving ...

Beyond Serendipity: Redefining Rational Molecular Glue Discovery via AI-driven methodologies As a new generation of ...

A new method screens large libraries of synthetic cyclic peptides to identify compounds that can enter cells for therapeutic effect.

How do bacteria regulate the production of their proteins? Researchers at the University of Hamburg, in collaboration with ...

Membrane proteins and membrane lipids are essential partners in various biological processes, and elucidating their structures in a natural membrane environment is crucial for enhancing our ...