Cardiomyocytes comprise 70–80% of the mass of the adult heart ... cardiomyocyte hypertrophy appears to be regulated in large part through stimulation of G-protein coupled receptors (GPCRs).

glycogen synthase kinase-3 (GSK-3) proteins include the isoforms GSK-3beta and GSK-3alpha. GSK-3beta has always been thought to be the regulator of cardiac hypertrophy, and GSK-3alpha has been ...

The childhood onset of idiopathic cardiac hypertrophy ... eight sarcomere proteins, PRKAG2, and LAMP2 in 84 children with isolated, idiopathic left ventricular hypertrophy diagnosed before 15 ...

Now, a study published in the journal Cellular and Molecular Life Sciences has identified a new factor linked to the development of pathological hypertrophy. The results of the study suggest that ...

A detailed dissection of mechanisms governing cardiac plasticity raises the prospect of enhancing the advantageous features of hypertrophy (e.g., decreased wall stress) while inhibiting the ...

When the workload on the heart increases, the ventricular wall may thicken too, known as cardiac hypertrophy. This is an adaptive response that reduces pressure on the heart and maintains the activity ...

New treatments for cardiac hypertrophy ... lead to hypertrophy. One of them is called the calcineurin (calcineurin-nuclear factor of activated T cells) pathway and the other the CaMKII ...

glycogen synthase kinase-3 (GSK-3) proteins include the isoforms GSK-3beta and GSK-3alpha. GSK-3beta has always been thought to be the regulator of cardiac hypertrophy, and GSK-3alpha has been ...