Cardiomyocytes comprise 70–80% of the mass of the adult heart ... cardiomyocyte hypertrophy appears to be regulated in large part through stimulation of G-protein coupled receptors (GPCRs).

The childhood onset of idiopathic cardiac hypertrophy ... eight sarcomere proteins, PRKAG2, and LAMP2 in 84 children with isolated, idiopathic left ventricular hypertrophy diagnosed before 15 ...

glycogen synthase kinase-3 (GSK-3) proteins include the isoforms GSK-3beta and GSK-3alpha. GSK-3beta has always been thought to be the regulator of cardiac hypertrophy, and GSK-3alpha has been ...

Mfn2 is highlighted as a key protein whose expression is negatively associated with cardiac hypertrophy. The study suggests that by promoting Mfn2 expression, ZNF593-AS can counteract the ...

Our article entitled “Pharmacological protein kinase C modulators reveal ... mechanisms of endothelin-1-induced hypertrophy. Hypertrophy of cardiomyocytes is initially a compensatory mechanism to ...

Now, a study published in the journal Cellular and Molecular Life Sciences has identified a new factor linked to the development of pathological hypertrophy. The results of the study suggest that ...

Scientists have implicated the histone trimethyl demethylase protein JMJD2A in the development of cardiac hypertrophy. Using mouse models in which the JMJD2A gene was either knocked out or ...

deletion of GADD45A also caused substantial cardiac hypertrophy that negatively affected cardiac morphology and function in mice lacking this protein. Furthermore, overexpression of GADD45A in human ...

A natural compound from magnolia bark can protect the heart from hypertrophy by activating SIRT3, a protein associated with delayed aging, stress resistance and metabolic regulation. Injected ...

Inhibiting the activity of a specific calcium-regulating membrane protein may prevent the thickening of heart muscle tissues, a disorder known as cardiac hypertrophy, a new study finds 1. This insight ...

glycogen synthase kinase-3 (GSK-3) proteins include the isoforms GSK-3beta and GSK-3alpha. GSK-3beta has always been thought to be the regulator of cardiac hypertrophy, and GSK-3alpha has been ...