Northwestern Medicine scientists have zeroed in on a cellular gatekeeper that may hold promise for treating abnormal protein ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted, but are of great clinical significance.

Researchers have developed smart nanoparticles that can seek out and destroy disease-causing proteins the body can’t normally eliminate. Unlike traditional drugs, these particles can reach ...

Targeted protein degradation has opened up a new field of drug discovery with potential to treat previously 'undruggable' diseases. The work means new drugs can be much more accurately targeted at the ...