Inhibition of αv-integrins by a cyclic RGD-peptide resulted in significant reduction of functional vessel density, retardation of tumour growth and metastasis in vivo.

An internalising RGD cyclic peptide product, certepetide is designed to selectively activate the C-end rule active transport mechanism, enhancing the penetration and accumulation of systemically ...

As part of its GO™ Peptides collection, AnaSpec has introduced a selection of cyclic and non-cyclic RGD peptides. The RGD (Arg-Gly-Asp) tripeptide motif can be found in extracellular matrix (ECM) ...

In a recent achievement, DP Technology's hit discovery platform RiDYMO® has successfully designed a cyclic peptide targeting β-catenin, a historically "undruggable" protein, in just two months.

Beta peptides have become a key tool in building more robust biomaterials. ... Using beta-foldamers with RGD at the center, the team constructed a mesh on which they cultured a network of neurons.

From a phage library listing cyclic peptides with 10 9 types of amino acid sequences, the researchers searched for phages able to penetrate human BBB model cells and analyzed their sequences.

Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology.

Considering that orally administered cyclic peptides generally show a bioavailability below 2%, an oral bioavailability of 18% is a substantial advance for peptide-based biologic drugs.

Cyclic peptides, which combine characteristics of both small molecules and proteins, have emerged as significant molecules for regulating protein–protein interactions (PPIs).

An internalising RGD cyclic peptide product, certepetide is designed to selectively activate the C-end rule active transport mechanism, enhancing the penetration and accumulation of systemically ...