Mild to moderate diarrhea was the most common (55%) treatment-related adverse event. The maximum-tolerated dose was 400 mg bid continuous. Dose-limiting toxicities were grade 3 diarrhea and fatigue at ...
Haisco Pharmaceutical Group Co. Ltd. has disclosed Raf kinase B (V600E mutant) inhibitors reported to be useful for the treatment of cancer.
Shenzhen Targetrx Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN)-binding moiety covalently linked to Raf kinase B (V600E mutant)-targeting moiety ...
Key market opportunities include the growth of precision medicine, AI integration in drug discovery, increased R&D in ...
Molecular-Based Ecosystem to Improve Personalized Medicine in Chronic Myelomonocytic Leukemia Eighty patients (60% BRAFi-exposed)—63 with colorectal cancer (CRC), 13 with melanoma, and 4 with other ...
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