Enhancement of retroviral transduction efficiency has been achieved by several physical and chemical approaches. However, the application of those methods is hampered by not easily scalable ...

An elegant trick reported in this issue of Nature Methods should facilitate the generation of monospecific T-cell populations by retroviral transduction of hematopoietic stem cells 2.

S.A. Rosenberg, P. Aebersold, K. Cornetta, A. Kasid, et al., "Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral ...

Retroviral Vectors. ... However, for transduction to occur retrovirus cells require mitotic cell division to be in process, which puts a significant limit on their utility.

Viruses tend to have higher transduction efficiency compared with nonviral methods; during evolution, ... Retroviral vectors are ideal transfer vectors for gene therapy.

Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation. ... However, only ...

All of the patients tolerated the treatment well and none of the theoretic safety hazards due to the retroviral gene transduction was observed. The presence of the NeoR gene in TIL was detected by ...