Here, we describe human single-chain variable fragment (scFv) antibodies that target the ligand-binding domain (LBD) in ALK and show the effect in vitro and in vivo. The ALK LBD was used as a bait ...

Originally derived from camelid heavy chain antibodies, single domain or VHH antibodies can bind epitopes that are inaccessible to conventional monoclonal antibodies due to their small size. Because ...

known as single domain antibodies (sdAbs) or VHH ligands, has seen a tremendous uptake in various fields. sdAbs harbor the full antigen-binding capacity of the original heavy chain antibody, but the ...

requires just a single domain found on heavy chain only antibody. With VHH-based antibodies able to exhibit pharmaceutically-relevant properties comparable to IgGs, they are a promising ...

Single-domain antibodies are small enough to reach intracellular tau. Vaccines can go after multiple pathologies at once. A peptide-antibody fusion might opsonize ... variable heavy chain fragments ...

Allen Guo, CEO "We are excited to present our pre-clinical findings at the AACR, showcasing the significant potential of our CD3 agonistic single-domain antibody," said Allen Guo, CEO.

Since Emglev’s antibody scaffold is already humanized or derived from human variable region of the heavy chain (VH), there ... the therapeutic use of single-domain antibodies, focusing on ...

However, there is an important limitation of the currently reported single chain antibody used as a chimeric antigen receptor (CAR) targeting domain. Specifically, CAR aggregation leads to CAR-T ...

"Existing models for single domain antibody discovery often encounter ... we have extensively modified the immunoglobulin heavy chain locus to generate the Singularity Sapiens Mouse, which solely ...