Here, we describe human single-chain variable fragment (scFv) antibodies that target the ligand-binding domain (LBD) in ALK and show the effect in vitro and in vivo. The ALK LBD was used as a bait ...

known as single domain antibodies (sdAbs) or VHH ligands, has seen a tremendous uptake in various fields. sdAbs harbor the full antigen-binding capacity of the original heavy chain antibody, but the ...

Single-domain antibodies are small enough to reach intracellular tau. Vaccines can go after multiple pathologies at once. A peptide-antibody fusion might opsonize ... variable heavy chain fragments ...

However, there is an important limitation of the currently reported single chain antibody used as a chimeric antigen receptor (CAR) targeting domain. Specifically, CAR aggregation leads to CAR-T ...

Since Emglev’s antibody scaffold is already humanized or derived from human variable region of the heavy chain (VH), there ... the therapeutic use of single-domain antibodies, focusing on ...

"Existing models for single domain antibody discovery often encounter ... we have extensively modified the immunoglobulin heavy chain locus to generate the Singularity Sapiens Mouse, which solely ...

Allen Guo, CEO "We are excited to present our pre-clinical findings at the AACR, showcasing the significant potential of our CD3 agonistic single-domain antibody," said Allen Guo, CEO.

In a groundbreaking study, researchers now provide novel insights into the structure formed due to 3D domain swapping of the antibody light chain, the part of the antibody contributing to antigen ...

Since Emglev’s antibody scaffold is already humanized or derived from human variable region of the heavy chain (VH), there is no need for ... Valour Bio will focus on optimizing the therapeutic use of ...

Valour Bio has been established as a wholly owned subsidiary of Valerio Therapeutics to focus on discovering single domain antibodies ... barriers of conventional antibody discovery by providing ...